ExperimentList
Experiment #30
Name:	hon-2002-1
pubmed	12050673 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	2002
author-list	Hon et al.
Experiment #31
Name:	min-2002-1
pubmed	12004076 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	2002
author-list	Min et al.

InteractorList
Interactor #1
Name:	Hif1a: Hypoxia-inducible factor 1-alpha (gene name: HIF1A) (synonym: Member of PAS protein 1)
uniprot knowledge base	Q16665 [identical object]
refseq	NP_001521.1 [identical object]
ensembl	ENSG00000100644 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #2
Name:	pVHL: Von Hippel-Lindau disease tumor suppressor (gene name: VHL) (synonym: Protein G7)
uniprot knowledge base	P40337 [identical object]
refseq	NP_000542.1 [identical object]
ensembl	ENSG00000134086 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #3
Name:	Phd2: Egl nine homolog 1 (gene name: EGLN1) (synonym: Hypoxia-inducible factor prolyl hydroxylase 2)
uniprot knowledge base	Q9GZT9 [identical object]
refseq	NP_071334.1 [identical object]
ensembl	ENSG00000135766 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human

InteractionList
Interaction #4
Name:	Hif1a-Phd2
dip	DIP72125E [identical object]
Experiments:	hon-2002-1 min-2002-1
Participants:
Participant #11	Phd2 Biological Role: Name: enzyme psi-mi MI:0501 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #12	Hif1a Biological Role: Name: enzyme target psi-mi MI:0502 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #50 hydroxylated residue () [ 402 .. 402 ] resulting-ptm Feature #51 hydroxylated residue () [ 564 .. 564 ] resulting-ptm
Interaction Type:	Name: hydroxylation reaction psi-mi MI:0210
Interaction attributes:
cooperative mechanism	pre-assembly
affected interaction	Hif1a-pVHL
cooperative effect outcome	positive cooperative effect
pre-assembly response	altered physicochemical compatibility
Interaction #5
Name:	Hif1a-pVHL
wwpdb	1LQB [identical object]
wwpdb	1LM8 [identical object]
intact	EBI-1175463 [identical object]
Experiments:	hon-2002-1 min-2002-1
Participants:
Participant #13	Hif1a Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #52 hydroxylated residue () [ 402 .. 402 ] prerequisite-ptm Feature #53 hydroxylated residue () [ 564 .. 564 ] prerequisite-ptm
Participant #14	pVHL Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407