ExperimentList
Experiment #10
Name:	fiedler-2008-1
pubmed	18498752 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	2008
author-list	Fiedler et al.

InteractorList
Interactor #1
Name:	Pygo1: Pygopus homolog 1 (gene name: PYGO1)
uniprot knowledge base	Q9Y3Y4 [identical object]
refseq	NP_056432.1 [identical object]
ensembl	ENSG00000171016 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #2
Name:	Bcl9: B-cell CLL/lymphoma 9 protein (gene name: BCL9)
uniprot knowledge base	O00512 [identical object]
refseq	NP_004317.2 [identical object]
ensembl	ENSG00000116128 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #3
Name:	H3K4me2: Histone H3 peptide
intact	EBI-6146769 [identical object]
Interactor Type:	Name: peptide psi-mi MI:0327 [identical object]
Organism:	Human
Sequence:	ARTKQTA

InteractionList
Interaction #4
Name:	Pygo1-Bcl9
wwpdb	2VPD [identical object]
intact	EBI-6142511 [identical object]
Experiments:	fiedler-2008-1
Participants:
Participant #6	Pygo1 Biological Role: Name: allosteric molecule psi-mi MI:1159 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #7	Bcl9 Biological Role: Name: allosteric effector psi-mi MI:1160 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407
Interaction attributes:
cooperative mechanism	allostery
affected interaction	H3K4me2-Pygo1_Bcl9
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#6
allosteric effector	Participant#7
allosteric mechanism	allosteric change in structure
allosteric response	allosteric k-type response
allostery type	heterotropic allostery
cooperative effect value	2.58
Interaction #5
Name:	H3K4me2-Pygo1_Bcl9
wwpdb	2VPE [identical object]
intact	EBI-6146783 [identical object]
Experiments:	fiedler-2008-1
Participants:
Participant #8	Pygo1-Bcl9 Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #9	H3K4me2 Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #21 dimethylated residue () [ 4 .. 4 ] prerequisite-ptm
Interaction Type:	Name: direct interaction psi-mi MI:0407