ExperimentList
Experiment #30
Name:	cheng-2006-1
pubmed	16707497 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	2006
author-list	Cheng et al.
Experiment #31
Name:	stevenson-2002-1
pubmed	12081504 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	2002
author-list	Stevenson et al.
Experiment #32
Name:	jeffrey-1995-1
pubmed	7630397 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	1995
author-list	Jeffrey et al.
Experiment #33
Name:	Brown-1999-1
pubmed	10559988 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	1999
author-list	Brown et al.
Experiment #34
Name:	russo-1996-1
pubmed	8756328 [primary-reference]
Host Organism:	in vitro (taxid: -1)
Interaction detection method:	Name: inferred by author psi-mi MI:0363 [identical object]
Participant identification method:	Name: predetermined psi-mi MI:0396 [identical object]
publication year	1996
author-list	Russo et al.

InteractorList
Interactor #1
Name:	Cdk2: Cyclin-dependent kinase 2 (gene name: CDK2) (synonym: p33 protein kinase)
uniprot knowledge base	P24941 [identical object]
refseq	NP_001789.2 [identical object]
ensembl	ENSG00000123374 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #2
Name:	Ccna2: Cyclin-A2 (gene name: CCNA2) (synonym: CCN1)
uniprot knowledge base	P20248 [identical object]
refseq	NP_001228.1 [identical object]
ensembl	ENSG00000145386 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #3
Name:	Cdk7: Cyclin-dependent kinase 7 (gene name: CDK7) (synonym: CDK-activating kinase 1)
uniprot knowledge base	P50613 [identical object]
refseq	NP_001790.1 [identical object]
ensembl	ENSG00000134058 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human
Interactor #4
Name:	Cdc6: Cell division control protein 6 homolog (gene name: CDC6) (synonym: Cdc18-related protein)
uniprot knowledge base	Q99741
refseq	NP_001245.1 [identical object]
ensembl	ENSG00000094804 [gene product]
Interactor Type:	Name: protein psi-mi MI:0326 [identical object]
Organism:	Human

InteractionList
Interaction #5
Name:	CyclinA-Cdk2
wwpdb	1FIN [identical object]
intact	EBI-1030422 [identical object]
Experiments:	cheng-2006-1
Participants:
Participant #13	Cdk2 Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #14	Ccna2 Biological Role: Name: unspecified role psi-mi MI:0499 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407
Interaction attributes:
cooperative mechanism	pre-assembly
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
pre-assembly response	configurational pre-organization
Interaction #6
Name:	CyclinA-Cdk2
wwpdb	1FIN [identical object]
intact	EBI-1030422 [identical object]
Experiments:	stevenson-2002-1 jeffrey-1995-1
Participants:
Participant #15	Cdk2 Biological Role: Name: allosteric molecule psi-mi MI:1159 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #16	Ccna2 Biological Role: Name: allosteric effector psi-mi MI:1160 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407
Interaction attributes:
cooperative mechanism	allostery
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#15
allosteric effector	Participant#16
allosteric mechanism	allosteric change in structure
allosteric response	allosteric v-type response
allostery type	heterotropic allostery
Interaction #7
Name:	CyclinA-Cdk2
wwpdb	1FIN [identical object]
intact	EBI-1030422 [identical object]
Experiments:	stevenson-2002-1 jeffrey-1995-1
Participants:
Participant #17	Cdk2 Biological Role: Name: allosteric molecule psi-mi MI:1159 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #18	Ccna2 Biological Role: Name: allosteric effector psi-mi MI:1160 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407
Interaction attributes:
cooperative mechanism	allostery
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#17
allosteric effector	Participant#18
allosteric mechanism	allosteric change in structure
allosteric response	allosteric k-type response
allostery type	heterotropic allostery
Interaction #8
Name:	CyclinA-Cdk2
wwpdb	1FIN [identical object]
intact	EBI-1030422 [identical object]
Experiments:	jeffrey-1995-1
Participants:
Participant #19	Cdk2 Biological Role: Name: allosteric molecule psi-mi MI:1159 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Participant #20	Ccna2 Biological Role: Name: allosteric effector psi-mi MI:1160 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: direct interaction psi-mi MI:0407
Interaction attributes:
cooperative mechanism	allostery
affected interaction	CyclinA_Cdk2-Cdk7
affected interaction	CyclinA_Cdk2-Cdk7
affected interaction	CyclinA_Cdk2-Cdk7
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#19
allosteric effector	Participant#20
allosteric mechanism	allosteric change in structure
allosteric response	allosteric k-type response
allostery type	heterotropic allostery
Interaction #9
Name:	CyclinA_Cdk2-Cdk7
wwpdb	1JST [identical object]
dip	DIP57013E [identical object]
Experiments:	stevenson-2002-1 Brown-1999-1
Participants:
Participant #21	CyclinA-Cdk2 Biological Role: Name: enzyme target psi-mi MI:0502 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #50 phosphorylated residue () [ 160 .. 160 ] resulting-ptm participant-ref Participant#13
Participant #22	Cdk7 Biological Role: Name: enzyme psi-mi MI:0501 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: phosphorylation reaction psi-mi MI:0217
Interaction attributes:
cooperative mechanism	allostery
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#13
allosteric post-translational modification	Feature#50
allosteric mechanism	allosteric change in structure
allosteric response	allosteric k-type response
allostery type	heterotropic allostery
Interaction #10
Name:	CyclinA_Cdk2-Cdk7
wwpdb	1JST [identical object]
dip	DIP57013E [identical object]
Experiments:	stevenson-2002-1 russo-1996-1
Participants:
Participant #23	CyclinA-Cdk2 Biological Role: Name: enzyme target psi-mi MI:0502 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #51 phosphorylated residue () [ 160 .. 160 ] resulting-ptm participant-ref Participant#13
Participant #24	Cdk7 Biological Role: Name: enzyme psi-mi MI:0501 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: phosphorylation reaction psi-mi MI:0217
Interaction attributes:
cooperative mechanism	allostery
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
allosteric molecule	Participant#13
allosteric post-translational modification	Feature#51
allosteric mechanism	allosteric change in structure
allosteric response	allosteric v-type response
allostery type	heterotropic allostery
Interaction #11
Name:	CyclinA_Cdk2-Cdk7
wwpdb	1JST [identical object]
dip	DIP57013E [identical object]
Experiments:	cheng-2006-1 Brown-1999-1
Participants:
Participant #25	CyclinA-Cdk2 Biological Role: Name: enzyme target psi-mi MI:0502 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #52 phosphorylated residue () [ 160 .. 160 ] resulting-ptm participant-ref Participant#13
Participant #26	Cdk7 Biological Role: Name: enzyme psi-mi MI:0501 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object]
Interaction Type:	Name: phosphorylation reaction psi-mi MI:0217 [identical object]
Interaction attributes:
cooperative mechanism	pre-assembly
affected interaction	CyclinA_pCdk2-Cdc6
cooperative effect outcome	positive cooperative effect
pre-assembly response	altered physicochemical compatibility
Interaction #12
Name:	CyclinA_pCdk2-Cdc6
wwpdb	2CCI [identical object]
Experiments:	cheng-2006-1
Participants:
Participant #27	CyclinA-Cdk2 Biological Role: Name: enzyme psi-mi MI:0501 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #53 phosphorylated residue () [ 160 .. 160 ] prerequisite-ptm participant-ref Participant#13
Participant #28	Cdc6 Biological Role: Name: enzyme target psi-mi MI:0502 [identical object] Experimental Role: Name: unspecified role psi-mi MI:0499 [identical object] Feature #54 phosphorylated residue () [ 74 .. 74 ] resulting-ptm
Interaction Type:	Name: phosphorylation reaction psi-mi MI:0217 [identical object]